Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAzR3MKPOcAQ5W-QhPnWuqy5OkIIR5Xu9Qo7aebXTuPsc#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 wasQuotedFrom 16108063 provenance.
- _5 value "This model for reciprocal regulation of nuclear transport by NES masking is unique in the literature, although it is certainly possible that other heterodimers are regulated in a similar fashion. It is not yet known whether BRCA2 is regulated by nuclear-cytoplasmic shuttling. Functional implications of nuclear-cytoplasmic shuttling of BRCA1 and BARD1 Howdoes the nuclear shuttling ofBRCA1andBARD1regulate their function, and when does it occur? These questions are only now starting to be addressed. The only activity of either BRCA1orBARD1that is yet known to be influenced by nuclear import/export is their ability to induce apoptosis when overexpressed; apoptotic activity of both BRCA1(45) and of BARD1(51) is inhibited by at least 50% when the two proteins are co-expressed in cells." provenance.