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- s41467-022-29206-7 type ResearchPaper assertion.
- s41467-022-29206-7 type ScholarlyWork provenance.
- s41467-022-29206-7 type ScholarlyWork provenance.
- s41467-022-29206-7 isPartOf 2041-1723 assertion.
- s41467-022-29206-7 title "The induction of natural competence adapts staphylococcal metabolism to infection" assertion.
- s41467-022-29206-7 abstract "A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection." assertion.
- s41467-022-29206-7 date "2022-03-21" assertion.
- s41467-022-29206-7 volume "2022" assertion.
- s41467-022-29206-7 issue "13" assertion.