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- _8 label "Selventa" provenance.
- _8 comment "support@belframework.org" provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- small_corpus.bel version "20131211" provenance.
- small_corpus.bel authoredBy _8 provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion wasDerivedFrom _7 provenance.
- assertion hadPrimarySource 19570984 provenance.
- _7 wasQuotedFrom 19570984 provenance.
- _7 value "To confirm that EGFR internalization was critical for potentiating EGFR signaling, a GFP-tagged dominant negative dynamin (dn-dynamin) K44A expression construct was transiently transfected into A549 cells, and the impact of its expression on EGF-stimulated signaling was determined (Fig. 7A). The expression of dn-dynamin (Fig. 7B) resulted in a ~2-fold decrease in ERK1/2 activation in response to EGF stimulation (Fig. 7, A and C); this observation supports the conclusion that internalization of EGFR is critical for proper signaling in A549 cells." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.