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- _7 value "To confirm that EGFR internalization was critical for potentiating EGFR signaling, a GFP-tagged dominant negative dynamin (dn-dynamin) K44A expression construct was transiently transfected into A549 cells, and the impact of its expression on EGF-stimulated signaling was determined (Fig. 7A). The expression of dn-dynamin (Fig. 7B) resulted in a ~2-fold decrease in ERK1/2 activation in response to EGF stimulation (Fig. 7, A and C); this observation supports the conclusion that internalization of EGFR is critical for proper signaling in A549 cells." provenance.