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- _4 wasQuotedFrom _3 provenance.
- _4 value "the cellular concentration of malonyl-CoA is directly related to the activity of acetyl-CoA carboxylase the short-term regulation of acetyl-CoA carboxylase involves the phosphorylation and dephosphorylation of the enzyme in the fasting animal, a high [glucagon]/[insulin] ratio causes the phosphorylation and inactivation of acetyl-CoA carboxylase as a consequence, the concentration of malonyl-CoA and the rate of fatty acid synthesis decrease, while the rate of beta-oxidation increases a decrease of the [glucagon]/[insulin] ratio reverses these effects thus, both fatty acid synthesis and fatty acid oxidation are regulated by the ratio of [glucagon]/[insulin]" provenance.