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- _6 wasQuotedFrom 15917250 provenance.
- _6 value "Activated Yes rapidly associates with the EGFR and triggers its phosphorylation at tyrosine residues Tyr845 and Tyr1173. EGFRTyr845 is a known Src target (52), whereas Tyr1173 reflects an activating autophosphorylation site of the EGFR (53). Yes inhibition by SU6656 abolishes EGFR phosphorylation at both sites, whereas AG1478 inhibits EGFR-Tyr1173 phosphorylationbut not phosphorylation at Tyr845. These findings suggest that Yes activates the EGFR at Tyr845, which is followed by activating autophosphorylation at Tyr1173." provenance.